Manufacturing a probiotic involves growing bacteria on specialised food called the growth medium. This original food source supplies the bacteria with the best nutrients for their growth. Once the bacteria have grown, Natren keeps this growth medium also called the supernatant in their finished probiotic product whereas other companies may separate the bacteria from this valuable growth medium and throw it out as a waste product. This separation process can damage or render the bacteria lame, which provides little benefit to us. Leaving the supernatant in is advantageous as it can help buffer and protect the bacteria from our stomach acid. If you take it away from the bacteria the bacteria are not as protected. Also as the bacteria grow and eat the original food, they make their own vital micronutrients which become part of this medium making the supernatant excellent and rich for our health. Research has proven that probiotics with their supernatant intact are up to 50% more effective than probiotics without the supernatant.